First off, I'm highly irritable, but it's very fleeting (meaning I'm irritated for like 30 second and move on, lol), so it's all relative.
Little things: I have a few grammatical pet peeves. When people don't know the difference between loose and lose ... random apostrophes ... my name being misspelled despite the fact that my name is spelled out in my email address or username when the person is responding.
Big things: I won't comment on this for fear of offending people